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Efonidipine hydrochloride monoethanolate

CAS No. 111011-76-8

Efonidipine hydrochloride monoethanolate( NZ-105 hydrochloride monoethanolate )

Catalog No. M10410 CAS No. 111011-76-8

Efonidipine (NZ-105) is a potent, dual T-type and L-type calcium channel blocker.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 45 Get Quote
10MG 73 Get Quote
25MG 157 Get Quote
50MG 284 Get Quote
100MG 368 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
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Biological Information

  • Product Name
    Efonidipine hydrochloride monoethanolate
  • Note
    Research use only, not for human use.
  • Brief Description
    Efonidipine (NZ-105) is a potent, dual T-type and L-type calcium channel blocker.
  • Description
    Efonidipine (NZ-105) is a potent, dual T-type and L-type calcium channel blocker, exhibits antihypertensive effect through vasodilatation; increases coronary blood flow by blocking L & T-type calcium channels and attenuates myocardial ischaemia, lowers blood pressure in cerebral resistance vessels and prevents hypertension induced brain damage; increases glomerular filtration rate without increasing intra-glomerular pressure and filtration fraction.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NZ-105 hydrochloride monoethanolate
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Calcium Channel
  • Research Area
    Cardiovascular Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    111011-76-8
  • Formula Weight
    714.1846
  • Molecular Formula
    C36H45ClN3O8P
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 8.5 mg/mL
  • SMILES
    CCO.CC1=C(C(C(=C(N1)C)P2(=O)OCC(CO2)(C)C)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5.Cl
  • Chemical Name
    3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, hydrochloride, compd. with 2-[phenyl(phenylmethyl)amino]ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Masuda Y, et al. Arch Int Pharmacodyn Ther. 1990 Mar-Apr;304:247-64. 2. Tamura T, et al. Naunyn Schmiedebergs Arch Pharmacol. 1991 Apr;343(4):405-10. 3. Shudo C, et al. Gen Pharmacol. 1994 Nov;25(7):1451-8. 4. Yamashita T, et al. Jpn J Pharmacol. 1991 Nov;57(3):337-48.
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